L Kynurenine Hydrolase (KYNU) (NM_001032998) Human Recombinant Protein

• Background:

  Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

• Synonyms:

  KYNUU; VCRL2

• Gene ID:

  8942

• UniProt:

  Q16719

• Accession Number mRNA:

  NM_001032998

• Chromosomal Location:

  2q22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Metabolic pathways, Tryptophan metabolism

• Field of Research:

  Metabolic pathways, Tryptophan metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Protease

• Molecular Weight:

  34.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KYNU

• Species:

  Human

• Protein ID:

  NP_001028170

• Overview:

  Recombinant protein of human kynureninase (L-kynurenine hydrolase) (KYNU), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8942

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16719

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001032998

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001028170