EBP50 (SLC9A3R1) (NM_004252) Human Recombinant Protein

• Background:

  This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

• Synonyms:

  EBP50; NHERF; NHERF-1; NHERF1; NPHLOP2

• Gene ID:

  9368

• UniProt:

  O14745

• Accession Number mRNA:

  NM_004252

• Chromosomal Location:

  17q25.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  26142394

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  38.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SLC9A3R1

• Species:

  Human

• Protein ID:

  NP_004243

• Overview:

  Purified recombinant protein of Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (SLC9A3R1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9368

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14745

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004252

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004243