NM23A (NME1) (NM_000269) Human Recombinant Protein

• Background:

  This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

• Synonyms:

  AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1

• Gene ID:

  4830

• UniProt:

  P15531, A0A384MTW7

• Accession Number mRNA:

  NM_000269

• Chromosomal Location:

  17q21.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Metabolic pathways, Purine metabolism, Pyrimidine metabolism

• Field of Research:

  Metabolic pathways, Purine metabolism, Pyrimidine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency

• Molecular Weight:

  17 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NME1

• Species:

  Human

• Protein ID:

  NP_000260

• Overview:

  Recombinant protein of human non-metastatic cells 1, protein (NM23A) expressed in (NME1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4830

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15531

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000269

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000260