RAB7 (RAB7A) (NM_004637) Human Recombinant Protein

• Background:

  RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

• Synonyms:

  CMT2B; PRO2706; RAB7

• Gene ID:

  7879

• UniProt:

  P51149, A0A158RFU6

• Accession Number mRNA:

  NM_004637

• Chromosomal Location:

  3q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  23.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RAB7A

• Species:

  Human

• Protein ID:

  NP_004628

• Overview:

  Recombinant protein of human RAB7A, member RAS oncogene family (RAB7A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7879

• Uniprot URL:

  https://www.uniprot.org/uniprot/P51149

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004637

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004628