ASCC1 (NM_015947) Human Recombinant Protein

• Background:

  This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF) . The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

• Synonyms:

  ASC1p50; CGI-18; RP11-150D20.4

• Gene ID:

  51008

• UniProt:

  Q8N9N2

• Accession Number mRNA:

  NM_015947

• Chromosomal Location:

  10q22.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  41 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ASCC1

• Species:

  Human

• Protein ID:

  NP_057031

• Overview:

  Recombinant protein of human activating signal cointegrator 1 complex subunit 1 (ASCC1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51008

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8N9N2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015947

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057031