MTGR1 (CBFA2T2) (NM_001039709) Human Recombinant Protein

• Background:

  In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

• Synonyms:

  EHT; MTGR1; p85; ZMYND3

• Gene ID:

  9139

• UniProt:

  O43439

• Accession Number mRNA:

  NM_001039709

• Chromosomal Location:

  20q11.21-q11.22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  63.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CBFA2T2

• Species:

  Human

• Protein ID:

  NP_001034798

• Overview:

  Recombinant protein of human core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9139

• Uniprot URL:

  https://www.uniprot.org/uniprot/O43439

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001039709

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001034798