DRP1 (DNM1L) (NM_012063) Human Recombinant Protein

• Background:

  This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) . Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

• Synonyms:

  DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV; OPA5

• Gene ID:

  10059

• UniProt:

  O00429, B4DYR6

• Accession Number mRNA:

  NM_012063

• Chromosomal Location:

  12p11.21

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis, Fc gamma R-mediated phagocytosis

• Field of Research:

  Endocytosis, Fc gamma R-mediated phagocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  79.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DNM1L

• Species:

  Human

• Protein ID:

  NP_036193

• Overview:

  Recombinant protein of human dynamin 1-like (DNM1L), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10059

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00429

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012063

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036193