BPGM (NM_199186) Human Recombinant Protein

• Background:

  2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

• Synonyms:

  DPGM; ECYT8

• Gene ID:

  669

• UniProt:

  P07738, A0A024R782

• Accession Number mRNA:

  NM_199186

• Chromosomal Location:

  7q33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Glycolysis / Gluconeogenesis, Metabolic pathways

• Field of Research:

  Glycolysis / Gluconeogenesis, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  29.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BPGM

• Species:

  Human

• Protein ID:

  NP_954655

• Overview:

  Recombinant protein of human 2, 3-bisphosphoglycerate mutase (BPGM), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/669

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07738

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_199186

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_954655