MTHFD2 (NM_006636) Human Recombinant Protein

• Background:

  This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]

• Synonyms:

  NMDMC

• Gene ID:

  10797

• UniProt:

  P13995

• Accession Number mRNA:

  NM_006636

• Chromosomal Location:

  2p13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Glyoxylate and dicarboxylate metabolism, Metabolic pathways, One carbon pool by folate

• Field of Research:

  Glyoxylate and dicarboxylate metabolism, Metabolic pathways, One carbon pool by folate

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  34.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MTHFD2

• Species:

  Human

• Protein ID:

  NP_006627

• Overview:

  Recombinant protein of human methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2), nuclear gene encoding mitochondrial protein, tra

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10797

• Uniprot URL:

  https://www.uniprot.org/uniprot/P13995

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006636

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006627