HCE (RNGTT) (NM_003800) Human Recombinant Protein

• Background:

  Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  CAP1A; hCAP; HCE; HCE1

• Gene ID:

  8732

• UniProt:

  O60942, Q7Z3R6

• Accession Number mRNA:

  NM_003800

• Chromosomal Location:

  6q15

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  68.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RNGTT

• Species:

  Human

• Protein ID:

  NP_003791

• Overview:

  Recombinant protein of human RNA guanylyltransferase and 5'-phosphatase (RNGTT)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8732

• Uniprot URL:

  https://www.uniprot.org/uniprot/O60942

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003800

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003791