IMPDH2 (NM_000884) Human Recombinant Protein

• Background:

  This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

• Synonyms:

  IMPD2; IMPDH-II

• Gene ID:

  3615

• UniProt:

  P12268, A0A384N6C2

• Accession Number mRNA:

  NM_000884

• Chromosomal Location:

  3p21.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

• Field of Research:

  Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  55.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  IMPDH2

• Species:

  Human

• Protein ID:

  NP_000875

• Overview:

  Recombinant protein of human IMP (inosine monophosphate) dehydrogenase 2 (IMPDH2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3615

• Uniprot URL:

  https://www.uniprot.org/uniprot/P12268

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000884

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000875