GPATCH3 (NM_022078) Human Recombinant Protein

• Background:

  Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860) . Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  GPATC3

• Gene ID:

  63906

• UniProt:

  Q96I76

• Accession Number mRNA:

  NM_022078

• Chromosomal Location:

  1p36.11

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  59.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GPATCH3

• Species:

  Human

• Protein ID:

  NP_071361

• Overview:

  Recombinant protein of human G patch domain containing 3 (GPATCH3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/63906

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96I76

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022078

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_071361