Cathepsin L (CTSL) (NM_001912) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]

• Synonyms:

  CATL; CTSL1; MEP

• Gene ID:

  1514

• UniProt:

  P07711, A0A024R276

• Accession Number mRNA:

  NM_001912

• Chromosomal Location:

  9q21.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Antigen processing and presentation, Lysosome

• Field of Research:

  Antigen processing and presentation, Lysosome

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease

• Molecular Weight:

  35.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CTSL

• Species:

  Human

• Protein ID:

  NP_001903

• Overview:

  Recombinant protein of human cathepsin L1 (CTSL1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1514

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07711

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001912

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001903