TRIP15 (COPS2) (NM_004236) Human Recombinant Protein

• Background:

  Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  ALIEN; CSN2; SGN2; TRIP15

• Gene ID:

  9318

• UniProt:

  P61201

• Accession Number mRNA:

  NM_004236

• Chromosomal Location:

  15q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  51.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  COPS2

• Species:

  Human

• Protein ID:

  NP_004227

• Overview:

  Recombinant protein of human COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (COPS2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9318

• Uniprot URL:

  https://www.uniprot.org/uniprot/P61201

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004236

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004227