Phospholipase A2 IIA (PLA2G2A) (NM_000300) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the phospholipase A2 family (PLA2) . PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

• Synonyms:

  MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2

• Gene ID:

  5320

• UniProt:

  P14555, A0A024RA96

• Accession Number mRNA:

  NM_000300

• Chromosomal Location:

  1p36.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

• Field of Research:

  Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  13.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PLA2G2A

• Species:

  Human

• Protein ID:

  NP_000291

• Overview:

  Recombinant protein of human phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5320

• Uniprot URL:

  https://www.uniprot.org/uniprot/P14555

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000300

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000291