SETDB1 (NM_012432) Human Recombinant Protein

• Background:

  This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

• Synonyms:

  ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21

• Gene ID:

  9869

• UniProt:

  Q15047

• Accession Number mRNA:

  NM_012432

• Chromosomal Location:

  1q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Lysine degradation

• Field of Research:

  Lysine degradation

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  142.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SETDB1

• Species:

  Human

• Protein ID:

  NP_036564

• Overview:

  Purified recombinant protein of Homo sapiens SET domain, bifurcated 1 (SETDB1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9869

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15047

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012432

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036564