HSD17B8 (NM_014234) Human Recombinant Protein

• Background:

  In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

• Synonyms:

  D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1

• Gene ID:

  7923

• UniProt:

  Q92506, A0A1U9X7U3

• Accession Number mRNA:

  NM_014234

• Chromosomal Location:

  6p21.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Androgen and estrogen metabolism, Metabolic pathways

• Field of Research:

  Androgen and estrogen metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  26.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HSD17B8

• Species:

  Human

• Protein ID:

  NP_055049

• Overview:

  Recombinant protein of human hydroxysteroid (17-beta) dehydrogenase 8 (HSD17B8)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7923

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92506

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014234

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055049