Integrin beta 1 (ITGB1) (NM_002211) Human Recombinant Protein

• Background:

  Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB

• Gene ID:

  3688

• UniProt:

  P05556

• Accession Number mRNA:

  NM_002211

• Chromosomal Location:

  10p11.22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axon guidance, Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer

• Field of Research:

  Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axon guidance, Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

• Molecular Weight:

  86.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ITGB1

• Species:

  Human

• Protein ID:

  NP_002202

• Overview:

  Recombinant protein of human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3688

• Uniprot URL:

  https://www.uniprot.org/uniprot/P05556

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002211

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002202