ACCN4 (ASIC4) (NM_182847) Human Recombinant Protein

• Background:

  This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]

• Synonyms:

  ACCN4; BNAC4

• Gene ID:

  55515

• UniProt:

  Q96FT7

• Accession Number mRNA:

  NM_182847

• Chromosomal Location:

  2q35

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Ion Channels: Other

• Molecular Weight:

  69.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ASIC4

• Species:

  Human

• Protein ID:

  NP_878267

• Overview:

  Recombinant protein of human amiloride-sensitive cation channel 4, pituitary (ACCN4), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/55515

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96FT7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_182847

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_878267