LINGO1 (NM_032808) Human Recombinant Protein

• Background:

  Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321) . Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088) . Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  LERN1; LRRN6A; MRT64; UNQ201

• Gene ID:

  84894

• UniProt:

  Q96FE5

• Accession Number mRNA:

  NM_032808

• Chromosomal Location:

  15q24.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  69.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LINGO1

• Species:

  Human

• Protein ID:

  NP_116197

• Overview:

  Recombinant protein of human leucine rich repeat and Ig domain containing 1 (LINGO1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/84894

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96FE5

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_032808

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_116197