VPS33B (NM_018668) Human Recombinant Protein

• Background:

  Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Synonyms:

  FLJ14848

• Gene ID:

  26276

• UniProt:

  Q9H267, A0A0S2Z577

• Accession Number mRNA:

  NM_018668

• Chromosomal Location:

  15q26.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  70.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  VPS33B

• Species:

  Human

• Protein ID:

  NP_061138

• Overview:

  Recombinant protein of human vacuolar protein sorting 33 homolog B (yeast) (VPS33B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/26276

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9H267

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018668

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_061138