STK3 (NM_006281) Human Recombinant Protein

• Background:

  This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

• Synonyms:

  KRS1; MST2

• Gene ID:

  6788

• UniProt:

  Q13188, A0A384MR07

• Accession Number mRNA:

  NM_006281

• Chromosomal Location:

  8q22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  MAPK signaling pathway

• Field of Research:

  MAPK signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  56.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  STK3

• Species:

  Human

• Protein ID:

  NP_006272

• Overview:

  Recombinant protein of human serine/threonine kinase 3 (STE20 homolog, yeast) (STK3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6788

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13188

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006281

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006272