Inosine triphosphate pyrophosphatase (ITPA) (NM_033453) Human Recombinant Protein

• Background:

  This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

• Synonyms:

  C20orf37; DEE35; dJ794I6.3; HLC14-06-P; ITPase; My049; NTPase

• Gene ID:

  3704

• UniProt:

  Q9BY32, A0A0S2Z3W7

• Accession Number mRNA:

  NM_033453

• Chromosomal Location:

  20p13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

• Field of Research:

  Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  21.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ITPA

• Species:

  Human

• Protein ID:

  NP_258412

• Overview:

  Recombinant protein of human inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3704

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BY32

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_033453

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_258412