Glutamine Synthetase (GLUL) (NM_002065) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

• Synonyms:

  GLNS; GS; PIG43; PIG59

• Gene ID:

  2752

• UniProt:

  P15104, A8YXX4

• Accession Number mRNA:

  NM_002065

• Chromosomal Location:

  1q25.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, Nitrogen metabolism

• Field of Research:

  Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, Nitrogen metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  41.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GLUL

• Species:

  Human

• Protein ID:

  NP_002056

• Overview:

  Recombinant protein of human glutamate-ammonia ligase (glutamine synthetase) (GLUL), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2752

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15104

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002065

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002056