Gamma Catenin (JUP) (NM_002230) Human Recombinant Protein

• Background:

  This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

• Synonyms:

  ARVD12; CTNNG; DP3; DPIII; PDGB; PKGB

• Gene ID:

  3728

• UniProt:

  P14923, A0A0S2Z487

• Accession Number mRNA:

  NM_002230

• Chromosomal Location:

  17q21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

• Field of Research:

  Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  29178343

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  81.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  JUP

• Species:

  Human

• Protein ID:

  NP_002221

• Overview:

  Recombinant protein of human junction plakoglobin (JUP), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3728

• Uniprot URL:

  https://www.uniprot.org/uniprot/P14923

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002230

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002221