Tcl1 (TCL1A) (NM_021966) Human Recombinant Protein

• Background:

  Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR) -alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]) . In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]) .[supplied by OMIM, Jul 2010]

• Synonyms:

  TCL1

• Gene ID:

  8115

• UniProt:

  P56279, A0A024R6G5

• Accession Number mRNA:

  NM_021966

• Chromosomal Location:

  14q32.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  13.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TCL1A

• Species:

  Human

• Protein ID:

  NP_068801

• Overview:

  Recombinant protein of human T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8115

• Uniprot URL:

  https://www.uniprot.org/uniprot/P56279

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021966

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_068801