ARSA (NM_000487) Human Recombinant Protein

• Background:

  The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]

• Synonyms:

  ASA; MLD

• Gene ID:

  410

• UniProt:

  P15289, A0A0C4DFZ2, B4DVI5

• Accession Number mRNA:

  NM_000487

• Chromosomal Location:

  22q13.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Lysosome, Sphingolipid metabolism

• Field of Research:

  Lysosome, Sphingolipid metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  51.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ARSA

• Species:

  Human

• Protein ID:

  NP_000478

• Overview:

  Recombinant protein of human arylsulfatase A (ARSA), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/410

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15289

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000487

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000478