Beta glucuronidase (GUSB) (NM_000181) Human Recombinant Protein

• Background:

  This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

• Synonyms:

  BG; MPS7

• Gene ID:

  2990

• UniProt:

  P08236

• Accession Number mRNA:

  NM_000181

• Chromosomal Location:

  7q11.21

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism

• Field of Research:

  Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  72.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GUSB

• Species:

  Human

• Protein ID:

  NP_000172

• Overview:

  Recombinant protein of human glucuronidase, beta (GUSB)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2990

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08236

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000181

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000172