SLP76 (LCP2) (NM_005565) Human Recombinant Protein

• Background:

  This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR) -activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

• Synonyms:

  IMD81; SLP-76; SLP76

• Gene ID:

  3937

• UniProt:

  Q13094

• Accession Number mRNA:

  NM_005565

• Chromosomal Location:

  5q35.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Field of Research:

  Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  60 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LCP2

• Species:

  Human

• Protein ID:

  NP_005556

• Overview:

  Recombinant protein of human lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3937

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13094

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005565

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005556