HEPC (HAMP) (NM_021175) Human Recombinant Protein

• Background:

  The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

• Synonyms:

  HEPC; HFE2B; LEAP1; PLTR

• Gene ID:

  57817

• UniProt:

  P81172

• Accession Number mRNA:

  NM_021175

• Chromosomal Location:

  19q13.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein, Transmembrane

• Molecular Weight:

  6.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HAMP

• Species:

  Human

• Protein ID:

  NP_066998

• Overview:

  Recombinant protein of human hepcidin antimicrobial peptide (HAMP)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/57817

• Uniprot URL:

  https://www.uniprot.org/uniprot/P81172

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021175

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_066998