Langerin (CD207) (NM_015717) Human Recombinant Protein

• Background:

  The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

• Synonyms:

  CLEC4K

• Gene ID:

  50489

• UniProt:

  Q9UJ71

• Accession Number mRNA:

  NM_015717

• Chromosomal Location:

  2p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  36.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CD207

• Species:

  Human

• Protein ID:

  NP_056532

• Overview:

  Recombinant protein of human CD207 molecule, langerin (CD207)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/50489

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UJ71

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015717

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_056532