PI 3 Kinase Class 3 (PIK3C3) (NM_002647) Human Recombinant Protein

• Background:

  Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530) . Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  HVps34; VPS34; Vps34

• Gene ID:

  5289

• UniProt:

  Q8NEB9

• Accession Number mRNA:

  NM_002647

• Chromosomal Location:

  18q12.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of autophagy

• Field of Research:

  Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of autophagy

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  101.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PIK3C3

• Species:

  Human

• Protein ID:

  NP_002638

• Overview:

  Recombinant protein of human phosphoinositide-3-kinase, class 3 (PIK3C3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5289

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8NEB9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002647

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002638