ITPKA (NM_002220) Human Recombinant Protein

• Background:

  Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins (1,3,4,5) P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

• Synonyms:

  IP3-3KA; IP3KA

• Gene ID:

  3706

• UniProt:

  P23677

• Accession Number mRNA:

  NM_002220

• Chromosomal Location:

  15q15.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Calcium signaling pathway, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

• Field of Research:

  Calcium signaling pathway, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  50.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ITPKA

• Species:

  Human

• Protein ID:

  NP_002211

• Overview:

  Recombinant protein of human inositol 1, 4, 5-trisphosphate 3-kinase A (ITPKA)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3706

• Uniprot URL:

  https://www.uniprot.org/uniprot/P23677

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002220

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002211