ID2 (NM_002166) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

• Synonyms:

  BHLHb26; GIG8; ID2A; ID2H

• Gene ID:

  3398

• UniProt:

  Q02363, Q53T66

• Accession Number mRNA:

  NM_002166

• Chromosomal Location:

  2p25.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  TGF-beta signaling pathway

• Field of Research:

  TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  ES Cell Differentiation/IPS, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors

• Molecular Weight:

  14.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ID2

• Species:

  Human

• Protein ID:

  NP_002157

• Overview:

  Recombinant protein of human inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3398

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q02363

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002166

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002157