ADH1B (NM_000668) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

• Synonyms:

  ADH2; HEL-S-117

• Gene ID:

  125

• UniProt:

  P00325, V9HW50

• Accession Number mRNA:

  NM_000668

• Chromosomal Location:

  4q23

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Drug metabolism - cytochrome P450, Fatty acid metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tyrosine metabolism

• Field of Research:

  Drug metabolism - cytochrome P450, Fatty acid metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tyrosine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  39.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ADH1B

• Species:

  Human

• Protein ID:

  NP_000659

• Overview:

  Recombinant protein of human alcohol dehydrogenase 1B (class I), beta polypeptide (ADH1B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/125

• Uniprot URL:

  https://www.uniprot.org/uniprot/P00325

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000668

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000659