Calpain 2 (CAPN2) (NM_001748) Human Recombinant Protein

• Background:

  The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

• Synonyms:

  CANP2; CANPL2; CANPml; mCANP

• Gene ID:

  824

• UniProt:

  P17655, Q59EF6

• Accession Number mRNA:

  NM_001748

• Chromosomal Location:

  1q41

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alzheimer's disease, Apoptosis, Focal adhesion

• Field of Research:

  Alzheimer's disease, Apoptosis, Focal adhesion

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease

• Molecular Weight:

  79.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CAPN2

• Species:

  Human

• Protein ID:

  NP_001739

• Overview:

  Recombinant protein of human calpain 2, (m/II) large subunit (CAPN2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/824

• Uniprot URL:

  https://www.uniprot.org/uniprot/P17655

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001748

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001739