CYP1A1 (NM_000499) Human Recombinant Protein

• Background:

  This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

• Synonyms:

  AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX

• Gene ID:

  1543

• UniProt:

  P04798, A0N0X8

• Accession Number mRNA:

  NM_000499

• Chromosomal Location:

  15q24.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tryptophan metabolism

• Field of Research:

  Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tryptophan metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, P450, Transmembrane

• Molecular Weight:

  58 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CYP1A1

• Species:

  Human

• Protein ID:

  NP_000490

• Overview:

  Recombinant protein of human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1543

• Uniprot URL:

  https://www.uniprot.org/uniprot/P04798

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000499

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000490