PIM1 (NM_002648) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810) .[provided by RefSeq, Aug 2011]

• Synonyms:

  PIM

• Gene ID:

  5292

• UniProt:

  P11309, A0A024RD25

• Accession Number mRNA:

  NM_002648

• Chromosomal Location:

  6p21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Acute myeloid leukemia, Jak-STAT signaling pathway

• Field of Research:

  Acute myeloid leukemia, Jak-STAT signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase

• Molecular Weight:

  35.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PIM1

• Species:

  Human

• Protein ID:

  NP_002639

• Overview:

  Recombinant protein of human pim-1 oncogene (PIM1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5292

• Uniprot URL:

  https://www.uniprot.org/uniprot/P11309

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002648

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002639