Neurofilament (NEFL) (NM_006158) Human Recombinant Protein

• Background:

  Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

• Synonyms:

  CMT1F; CMT2E; CMTDIG; NF-L; NF68; NFL; PPP1R110

• Gene ID:

  4747

• UniProt:

  P07196

• Accession Number mRNA:

  NM_006158

• Chromosomal Location:

  8p21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Amyotrophic lateral sclerosis (ALS)

• Field of Research:

  Amyotrophic lateral sclerosis (ALS)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS

• Molecular Weight:

  61.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NEFL

• Species:

  Human

• Protein ID:

  NP_006149

• Overview:

  Recombinant protein of human neurofilament, light polypeptide (NEFL)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4747

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07196

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006158

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006149