PDK2 (NM_002611) Human Recombinant Protein

• Background:

  This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

• Synonyms:

  PDHK2; PDKII

• Gene ID:

  5164

• UniProt:

  Q15119

• Accession Number mRNA:

  NM_002611

• Chromosomal Location:

  17q21.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  46 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDK2

• Species:

  Human

• Protein ID:

  NP_002602

• Overview:

  Recombinant protein of human pyruvate dehydrogenase kinase, isozyme 2 (PDK2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5164

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15119

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002611

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002602