KTEL1 (POGLUT1) (NM_152305) Human Recombinant Protein

• Background:

  This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Synonyms:

  C3orf9; CLP46; hCLP46; KDELCL1; KTELC1; LGMD2Z; LGMDR21; MDS010; MDSRP; Rumi

• Gene ID:

  56983

• UniProt:

  Q8NBL1

• Accession Number mRNA:

  NM_152305

• Chromosomal Location:

  3q13.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  46 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  POGLUT1

• Species:

  Human

• Protein ID:

  NP_689518

• Overview:

  Recombinant protein of human KTEL (Lys-Tyr-Glu-Leu) containing 1 (KTELC1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/56983

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8NBL1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_152305

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_689518