SCAP2 (SKAP2) (NM_003930) Human Recombinant Protein

• Background:

  The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

• Synonyms:

  PRAP; RA70; SAPS; SCAP2; SKAP-HOM; SKAP55R

• Gene ID:

  8935

• UniProt:

  O75563

• Accession Number mRNA:

  NM_003930

• Chromosomal Location:

  7p15.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  41 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SKAP2

• Species:

  Human

• Protein ID:

  NP_003921

• Overview:

  Recombinant protein of human src kinase associated phosphoprotein 2 (SKAP2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8935

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75563

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003930

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003921