EGLN2 (NM_053046) Human Recombinant Protein

• Background:

  The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]

• Synonyms:

  EIT-6; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1

• Gene ID:

  112398

• UniProt:

  Q96KS0, A0A024R0R2

• Accession Number mRNA:

  NM_053046

• Chromosomal Location:

  19q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Pathways in cancer, Renal cell carcinoma

• Field of Research:

  Pathways in cancer, Renal cell carcinoma

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  26751287

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  43.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EGLN2

• Species:

  Human

• Protein ID:

  NP_444274

• Overview:

  Recombinant protein of human egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/112398

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96KS0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_053046

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_444274