Dynamin 1 (DNM1) (NM_001005336) Human Recombinant Protein

• Background:

  This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Synonyms:

  DEE31; DNM; EIEE31

• Gene ID:

  1759

• UniProt:

  Q05193

• Accession Number mRNA:

  NM_001005336

• Chromosomal Location:

  9q34.11

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis, Fc gamma R-mediated phagocytosis

• Field of Research:

  Endocytosis, Fc gamma R-mediated phagocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  95.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DNM1

• Species:

  Human

• Protein ID:

  NP_001005336

• Overview:

  Recombinant protein of human dynamin 1 (DNM1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1759

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q05193

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001005336

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001005336