Fibromodulin (FMOD) (NM_002023) Human Recombinant Protein

• Background:

  Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

• Synonyms:

  FM; SLRR2E

• Gene ID:

  2331

• UniProt:

  Q06828, A0A024R971, Q12833, B3KS64

• Accession Number mRNA:

  NM_002023

• Chromosomal Location:

  1q32.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  25406462

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  41.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  FMOD

• Species:

  Human

• Protein ID:

  NP_002014

• Overview:

  Recombinant protein of human fibromodulin (FMOD)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2331

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q06828

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002023

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002014