ROR gamma (RORC) (NM_005060) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR

• Gene ID:

  6097

• UniProt:

  P51449, Q6I9R9

• Accession Number mRNA:

  NM_005060

• Chromosomal Location:

  1q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  58 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RORC

• Species:

  Human

• Protein ID:

  NP_005051

• Overview:

  Recombinant protein of human RAR-related orphan receptor C (RORC), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6097

• Uniprot URL:

  https://www.uniprot.org/uniprot/P51449

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005060

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005051