CD247 (NM_000734) Human Recombinant Protein

• Background:

  The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ

• Gene ID:

  919

• UniProt:

  P20963

• Accession Number mRNA:

  NM_000734

• Chromosomal Location:

  1q24.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Field of Research:

  Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  16.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CD247

• Species:

  Human

• Protein ID:

  NP_000725

• Overview:

  Recombinant protein of human CD247 molecule (CD247), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/919

• Uniprot URL:

  https://www.uniprot.org/uniprot/P20963

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000734

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000725