ARSB (NM_198709) Human Recombinant Protein

• Background:

  Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]

• Synonyms:

  ASB; G4S; MPS6

• Gene ID:

  411

• UniProt:

  P15848, A8K4A0

• Accession Number mRNA:

  NM_198709

• Chromosomal Location:

  5q14.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Glycosaminoglycan degradation, Lysosome, Metabolic pathways

• Field of Research:

  Glycosaminoglycan degradation, Lysosome, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  42.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ARSB

• Species:

  Human

• Protein ID:

  NP_942002

• Overview:

  Recombinant protein of human arylsulfatase B (ARSB), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/411

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15848

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_198709

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_942002