PDE1B (NM_000924) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

• Synonyms:

  HEL-S-79p; PDE1B1; PDES1B

• Gene ID:

  5153

• UniProt:

  Q01064, A0A024RB59

• Accession Number mRNA:

  NM_000924

• Chromosomal Location:

  12q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  61.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE1B

• Species:

  Human

• Protein ID:

  NP_000915

• Overview:

  Recombinant protein of human phosphodiesterase 1B, calmodulin-dependent (PDE1B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5153

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q01064

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000924

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000915