ALDH6A1 (NM_005589) Human Recombinant Protein

• Background:

  This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

• Synonyms:

  MMSADHA; MMSDH

• Gene ID:

  4329

• UniProt:

  Q02252, A0A024R6G4

• Accession Number mRNA:

  NM_005589

• Chromosomal Location:

  14q24.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Inositol phosphate metabolism, Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation

• Field of Research:

  Inositol phosphate metabolism, Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  54.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ALDH6A1

• Species:

  Human

• Protein ID:

  NP_005580

• Overview:

  Recombinant protein of human aldehyde dehydrogenase 6 family, member A1 (ALDH6A1), nuclear gene encoding mitochondrial protein

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4329

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q02252

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005589

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005580